目的 利用不同工艺制备姜黄素固体分散体,并对各姜黄素固体分散体的性质进行比较研究。方法 主要通过冷冻干燥法、共沉淀法和微波淬冷法制备姜黄素/泊洛沙姆407固体分散体,利用扫描电镜(SEM)、差式扫描量热(DSC)、粉末X射线衍射(XRD)和傅里叶变换红外光谱(FT-IR)对所得固体分散体进行内在性质分析,通过溶出及溶解度实验来研究各工艺所得固体分散体改善药物难溶性质的特征。结果 各工艺所得固体分散体内部药物以微晶形式存在,微波淬冷法比其他方法能更显著地改善姜黄素的溶出及溶解度。结论 本实验为难溶性中药姜黄素固体分散体的实际生产工艺选择提供参考。
Abstract
OBJECTIVE To prepare curcumin solid dispersions by different preparation technologies and compare their properties. METHODS Curcumin/poloxamer 407 solid dispersions were prepared by freeze-drying, co-precipitation and microwave/quench cooling methods, respectively. Internal properties of obtained solid dispersion were analyzed by SEM, DSC, XRD and FT-IR. The improvement effect on the insolubility of curcumin by making it into solid dispersions by different technologies was characterized by dissolution and solubility experiments. RESULTS Curcumin was dispersed in solid dispersions in micro-crystal form. Compared with other technologies, microwave/quench cooling method could significantly improve the solubility and dissolution of insoluble curcumin. CONCLUSION The study provides reference for choice of applicable production technology for solid dispersions of insoluble Chinese traditional medicine curcumin.
关键词
姜黄素 /
固体分散体 /
最佳制备工艺 /
性质
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Key words
curcumin /
solid dispersion /
optimal preparation technology /
property
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中图分类号：
R944
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参考文献
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脚注
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基金
吉林省教育厅资助项目(吉教科合字2015第401号);吉林市科技局科技计划资助项目(201464053);中国博士后科学基金面上项目(2015M571374);吉林省科技发展计划资助项目(20140311110YY)
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